Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 18;10:13945. doi: 10.1038/s41598-020-70848-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Hypothesis and workflow of the study. (A) This study hypothesized that sex-specific plasma miRs (derived from the X-chromosome) are differentially expressed in (female) patients with LVDD and HFpEF and associate with microvascular injury (defined by increased plasma Ang-2 levels). (B) In the workflow of the study we measured plasma Angiopoietin-2, X-chromosome located miRs and miRs that were previously found to associate with Ang-2 (Ref.^8,10,12) in plasma from female patients with asymptomatic LVDD (n = 13). Next, we measured these miRs in patients with LVDD (n = 122) compared to their controls (n = 244). Subsequently and following analysis of the results we selected miR-34a. -224 and -452 and measured their plasma levels in patients with HFpEF (n = 52) compared to their respective controls (n = 53).