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. 2020 Aug 18;10:13945. doi: 10.1038/s41598-020-70848-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma Ang-2 levels and circulating miR-34a, -224 and -452 in (female) DM patients with LVDD compared controls. (A) Particularly miR-34a displayed a significant correlation with Ang-2 in the total patient population of patients with LVDD (N = 366, R² 0.04, R = 0.21, p = 0.001, 95% CI 0.103–0.312). (B) Lower levels of miR-34a in diabetic patients with LVDD compared to diabetic patients without LVDD (Fold change 1.2, p = 0.02, 95% CI − 0.428 to 0.117). (C) Lower levels of miR-34a, in women with an eGFR < 60 ml/min and LVDD compared to women without LVDD (Fold change 1.9, p = 0.03, CI − 0.737 to − 0.030). (D) Decreased plasma miR-224 in women with an eGFR < 60 ml/min and LVDD compared to women without LVDD (Fold change 1.8, p = 0.04, CI − 1.998 to − 0.059) and (E) decreased miR-452 in women with an eGFR < 60 ml/min and LVDD compared to women without LVDD (Fold change 1.5, p = 0.04, CI − 1.213 to − 0.039). Relative miR-expression values are normalized to plasma miR-16 levels, presented as mean ± standard error of the mean (SEM) and group differences are depicted as *p ≤ 0.05. Correlations between variables were calculated using the Spearman rank correlation.