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. 2020 Aug 18;10:13945. doi: 10.1038/s41598-020-70848-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma Ang-2 levels and plasma miR-34a, -224 and -452 in (female) DM patients with HFpEF. (A) Increased plasma Ang-2 (Fold change 1.3, p = 0.02, 95% CI 110.5–980.9) levels in diabetic women with HFpEF compared to diabetic women without HFpEF (but not in diabetic HFpEF men compared to diabetic men without HFpEF), (B) miR-34a displayed a trend towards an increase in diabetic women with HFpEF compared to diabetic women without HFpEF only (Fold change 1.5, p = 0.08, 95% CI − 0.009 to 0.173). (C) Increased plasma levels of miR-224 (Fold change 0.57, p = 0.04, 95% CI − 0.452 to − 0.010) and (D) miR-452 (Fold change 0.58, p = 0.05, − 0.539 to − 0.002) in diabetic women with HFpEF compared to diabetic men with HFpEF. Relative miR expression values are normalized to plasma miR-16 levels, presented as mean ± standard error of the mean (SEM) and group differences are depicted as *p ≤ 0.05 according to a student T-test.