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. 2020 Jul 29;25(15):3437. doi: 10.3390/molecules25153437

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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In vivo aptamer-conjugated SPIO nanoparticles therapeutic efficacy assessed using noninvasive BLI. Representative bioluminescence images (upper row) and corresponding quantitative assessments of radiance efficiency (lower row) in 4T1 tumor-bearing mice. Noninvasive imaging protocols were performed pre- (t = 0; corresponding to three-weeks post-tumor cell inoculation in the mammary fat pad) and up to 28 days post-injection of three consecutive doses (24 h interval time) of different aptamer therapeutic formulations. Black arrows highlight the injection time points. (i) pre-injection; (ii) non-treated mice; (iii) SPION-A11R6; (iv) SPION-11R6; (v) SPION-Cl42RNA; (vi) combined SPION-11R6 and SPION-Cl42RNA mice injected groups. Data are expressed as mean ± SD, n = 3 per group.