Figure 9.

Schematic illustration and SEM micrograph of the incorporated star-shaped PLL/pDNA peptiplexes into collagen-based scaffold platform and in vivo transfection of autologous host cells with star-PLL/pDNA scaffold, showing prolonged, non-toxic transgene expression. Seven days post implantation, gene activated scaffolds demonstrated successful transfection of autologous host cells, as evidenced by the presence of GFP positive (green) cells. Adapted from [132], with permission. Copyright: 2019 Elsevier.