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. 2020 Jul 31;25(15):3482. doi: 10.3390/molecules25153482

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Schematic illustration of synthesis of the branched modified R9 (B-mR9) CPP and construction of pDNA and siRNA polyplexes. Positively charged B-mR9 can be complexed with negatively charged genes through electrostatic interactions. B-mR9 polyplexes were delivered into cells by means of CPP-mediated permeabilization. The branched structures of B-mR9 were then cleaved by the reductive conditions of the cytoplasm. Finally, pDNA or siRNA was released into the nucleus or cytoplasm, respectively. (B) Naked dye and B-mR9/siVEGF polyplexes were intravenously injected into NCI-H460 tumor-bearing mice and the biodistribution was observed over 48 h. Adapted and modified from [148], with permission. Copyright: 2017 Elsevier.