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. 2020 Jul 31;25(15):3482. doi: 10.3390/molecules25153482

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Schematic illustration of self-assembly of cationic disulfide cross-linked SHRss and its complexation with negatively charged siRNA. (B) In vivo distribution and gene silencing efficiency of naked Cy5-siRNA and SHRss2/Cy5-siRNA nanocomplexes, after tail vein injection into xenograft tumor bearing mice after 4 h (blue arrows indicate the location of xenograft tumors). (C) Luciferase activity of the tumor tissue lysate after Cy5-siRNA and SHRss2/Cy5-siRNA nanocomplexes injections. (D) Luminescent images of tumors before and after SHRss2/NC-siRNA or SHRss2/siLuc nanocomplex injections. Reproduced from [173], with permission. Copyright: 2015 American Chemical Society.