Figure 19.

(A) Design of NFP analogues to improve tumoral uptake, penetration, and local retention. (B) A table showing NFP analogue composition and surface charge. (C) Morphologies of GSH-NFP in PBS buffer (left) before freeze-drying in sucrose and after reconstitution in water (right). (D) Representative PET/CT whole body images of SCID mice bearing MDA-MB-468 tumors were acquired 2 and 7 days after injection. (E) Quantification of nanofibers (radioactivity) at the region of interest (ROI; tumor) was plotted to reveal the kinetic uptake and the retention properties of GSH-NFP at tumor sites. (F) The biodistribution of ⁸⁹Zr-NFP was determined in separate groups of animals. Reproduced from [78], with permission. Copyright: 2018 John Wiley & Sons.