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. 2020 Jul 31;25(15):3510. doi: 10.3390/molecules25153510

Figure 6.

Figure 6

Molecular interactions analyses. The reference inhibitor MTX and Hit compound interacted with essential residues in the active site of hDHFR. MTX in WT hDHFR (A), Hit in WT hDHFR (B), MTX in MT hDHFR (C) and Hit in MT hDHFR (D) are depicted as light blue, dark blue, pink, and magenta-colored stick representation. The H-bond forming residues of hDHFR are displayed as a brown stick model. H-bonding and bond distances are represented as green dashed lines and measured in angstrom (Å), respectively.