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. 2020 Aug 20;84(5):e13317. doi: 10.1111/aji.13317

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© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

PMC Copyright notice

COVID‐19 and placental ACE2 expression and its possible consequences. The SARS‐CoV‐2 can cause placental dysfunction by inducing systemic inflammation (cytokine storm), oxygenation abnormalities within the intervillous space (COVID 19‐associated coagulopathy and maternal pneumonia), or by directly infecting the placenta causing cell damage. Since ACE2 expression is highly expressed in early/mid‐pregnancy compared to term placentas, the viral entry and trophoblasts cell damage is more extensive in early/mid‐pregnancy compared to term