Table 1.
Clinical laboratory results
| Variable | SARS‐CoV‐2‐ | SARS‐CoV‐2+ | SARS‐CoV‐2‐ | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Reference range | Day −12 | Day −8 | Day −5 | Day 1 | Day 4 | Day 7 | Day 11 | Day 34 | Day 45 | |
| SARS‐CoV‐2 | (−) | (+) | (−) | (−) | ||||||
| Adenovirus | (+) | (−) | ||||||||
| Virus/Bacteria/Parasites | (−) | (−) | ||||||||
| Albumin (g/dL) | 2.9‐5.2 | 4.3 | 4.4 | 4 | 4.5 | 4.8 | ||||
| CRP (mg/mL) | 0‐5 | 35.1 | 23.2 | 9,6 | 5.8 | 5.8 | 6.6 | 7.2 | 19.5 | |
| AST (U/L) | <40 | 56 | 44 | 43 | 42 | 46 | ||||
| ALT (U/L) | <35 | 75 | 64 | 67 | 80 | 94 | ||||
| Ferritin (ng/mL) | 22‐322 | 24 | 248 | 169 | 157 | |||||
| eGFR (mL/min/1.73m2) | >75 | >90 | >90 | 85 | >90 | >90 | >90 | 88 | ||
| BUN (mg/dL) | 11‐49 | 57 | 38 | 35 | 62 | 80 | ||||
| SCr (mg/dL) | 0.7‐1‐3 | 0.98 | 0.85 | 1.01 | 1.03 | 1.07 | 1.11 | |||
| LDH (U/L) | 100‐190 | 253 | 213 | 232 | 269 | |||||
| Prothrombin time (s) | 11.9 | 12.7 | 12.5 | 11.9 | 11.9 | 11.5 | ||||
| Derived fibrinogen (mg/dL) | 150‐450 | 397 | 352 | 319 | 344 | 321 | 253 | |||
| Cephalin time (s) | 28.9 | 24.8 | 25.4 | 27.9 | 27.7 | 28.4 | ||||
| D‐dimer (ng/mL) | 0‐500 | 2114 | 1803 | 1844 | 1440 | 2150 | ||||
| WBC (x103/uL) | 3.9‐10.2 | 11.36 | 11.41 | 10.41 | 12.41 | 11.05 | 12.38 | 9.42 | 9.0 | |
| Neutrophils (x103/uL) | 1.5‐7.70 | 5.67 | 6.02 | 5.3 | 5.6 | 4.7 | 5 | 4.08 | 4.19 | |
| Lymphocytes (x103/uL) | 1.1‐4.5 | 1.91 | 1.71 | 1.47 | 2.54 | 2.19 | 2.85 | 2.33 | 1.82 | |
| Monocytes (x103/uL) | 0.10‐0.9 | 0.98 | 1 | 1.08 | 1.22 | 0.97 | 1.31 | 0.96 | 0.72 | |
| Eosinophils (x103/uL) | 0.02‐0.65 | 2.48 | 2.37 | 2.29 | 2.68 | 2.88 | 2.86 | 1.8 | 2.12 | |
| Platelets (x103/uL) | 150‐370 | 451 | 460 | 486 | 477 | 500 | 480 | 393 | 297 | |
| Total IgG (mg/dL) | 725‐1900 | 1890 | ||||||||
| IgG SARS‐CoV‐2 | (−) | |||||||||
| Total IgM (mg/dL) | 45‐280 | 52 | ||||||||
| IgM SARS‐CoV‐2 | (−) | |||||||||
| C3 (mg/dL) | 75‐135 | 131 | ||||||||
| C4 (mg/dL) | 14‐60 | 27.80 | ||||||||
| CD4+ SARS‐CoV‐2 | (−) | |||||||||
| CD8+ SARS‐CoV‐2 | (−) | |||||||||
| Tacrolimus (ng/mL) | 6‐8 | 4.3 | 13.9 | 9.3 | 3.2 | 7.2 | 7.6 | 7.5 | 8.6 | |
| Sirolimus (ng/mL) | 6‐8 | 10.3 | ||||||||
Values unbold were above reference range. Flow cytometry experiments: lymphocytes were gated according to their forward and side characteristics. CD4 and CD8 cells were previously defined as CD3+CD45RA‐7AAD‐.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CRP, C‐reactive protein; eGFP, estimated glomerular filtration rate (based on CKD‐EPI creatinine); LDH, lactate dehydrogenase; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2; Scr, serum creatinine; WBC, white blood cells.