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. 2020 Aug 12;11:988. doi: 10.3389/fphys.2020.00988

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Copyright © 2020 Shen, Zhang, Huang, Zhu, Qiu, Ma, Yang, Ding and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Isoquercitrin reduces soleus muscle mass loss caused by denervation (n = 6). (A) The ratio of muscles wet weight in each group. (B) Representative images of laminin-stained muscles cross-sections in each group. Green indicates laminin staining. Scale bar: 50 μm. (C) The histogram shown the cross-sectional area (CSA) of muscles in each group. Ctrl, control group; Den, denervation group; ISO-L, denervated target muscle plus low-dose isoquercitrin (10 mg/kg/d); ISO-M, denervated target muscle plus middle-dose isoquercitrin (20 mg/kg/d); ISO-H, denervated target muscle plus high-dose isoquercitrin (40 mg/kg/d). ^**p < 0.01 and ^****p < 0.0001 vs. Ctrl; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, and ^####p < 0.0001 vs. Den; ^&&p < 0.01 vs. ISO-L.