Table 6.
Outcomes | Number of trials | ||||
|
Favoring interventiona | Showing no significant difference between intervention and controlb | Favoring controlc | ||
Clinical outcomes |
|
|
|
||
|
Objectively measured |
|
|
|
|
|
|
Postprandial BGd | 1 [19] |
|
|
|
|
Right brachial-ankle pulse wave velocity |
|
1 [40] |
|
|
|
Left brachial-ankle pulse wave velocity |
|
1 [40] |
|
|
|
Adiponectin | 1 [40] |
|
|
|
|
High-sensitivity C-reactive protein |
|
1 [40] |
|
|
|
Interleukin-6 |
|
1 [40] |
|
|
|
Homeostatic model assessment of insulin resistance |
|
1 [40] |
|
|
|
Waist/hip ratio |
|
1 [44] |
|
|
|
Creatinine |
|
1 [44] |
|
|
|
Medication dose |
|
|
1 [35] |
|
|
Insulin dose |
|
1 [34] |
|
|
Self-reported |
|
|
|
|
|
|
Quality of life |
|
6 [24,28,30,32,44] |
|
|
|
Diabetes symptoms |
|
3 [29] |
|
Behavioral outcomes (self-reported) |
|
|
|
||
|
General health-related |
|
|
|
|
|
|
Lifestyle-/health-related activity |
|
4 [24,30,33] |
|
|
Specific disease-related |
|
|
|
|
|
|
Adherence to medication | 1 [33] | 5 [17,25,27,39,42] |
|
|
|
Adherence to physical activities | 1 [43] | 6 [25,27,30,39,41] |
|
|
|
Adherence to healthy diet | 1 [39] | 4 [25,30,41] |
|
|
|
Frequency of carbohydrate spacing | 1 [25] |
|
|
|
|
Frequency of smoking |
|
1 [27] |
|
|
|
Frequency of drinking |
|
1 [27] |
|
|
|
Frequency of communicating with physicians |
|
1 [33] |
|
|
|
Adherence to BG monitoring | 2 [25,33] |
|
|
|
|
Adherence to foot care | 1 [25] |
|
|
Knowledge outcomes (self-reported) |
|
|
|
||
|
Diabetes knowledge | 1 [24] | 3 [25,33,37] |
|
|
|
Hypertension knowledge |
|
3 [17,35,37] |
|
|
Psychosocial outcomes (self-reported) |
|
|
|
||
|
Satisfaction |
|
|
|
|
|
|
Satisfaction with diabetes treatment | 1 [31] | 1 [33] |
|
|
|
Satisfaction with life |
|
1 [28] |
|
|
Self-efficacy |
|
|
|
|
|
|
Ability to interact with health organizations and HCPse |
|
2 [30] |
|
|
|
Ability to monitor the conditions and having insights into living with the conditions |
|
2 [30] |
|
|
|
Self-efficacy for medication taking/coping with diseases |
|
4 [17,24,25,33] |
|
|
Emotion |
|
|
|
|
|
|
Emotional well-being |
|
2 [30] |
|
|
|
Positive emotion |
|
1 [28] |
|
|
|
Negative emotion |
|
1 [28] |
|
|
|
Distress |
|
4 [29,33] |
|
|
|
Depression |
|
7 [24,28-30] | 1 [34] |
|
|
Anxiety |
|
2 [28,34] |
|
|
Perceived behavioral control |
|
|
|
|
|
|
Comfort with self-monitoring |
|
1 [34] |
|
|
|
Self-autonomous regulation |
|
1 [17] |
|
|
|
Determination about not allowing illnesses to control life |
|
2 [30] |
|
|
|
Positive and active engagement in life |
|
2 [30] |
|
|
|
Feeling of having the skills to manage disease | 1 [30] | 1 [30] |
|
|
|
Feeling of having social support |
|
2 [30] |
|
aSignificant improvement in the outcome at the end of the trial in the intervention group compared with the control group.
bNo significant difference in the outcome at the end of the trial between the intervention and control groups.
cSignificant deterioration in the outcome at the end of the trial in the intervention group compared with the control group.
dBG: blood glucose.
eHCP: health care provider.