Table 2.

Examples of MTDLs based on tacrine and donepezil scaffolds.

Scaffold	Lead Fragment	Targets	Ref.
Tacrine	xanomeline, iperoxo-fragment	AChE Is and MRs	[99]
	valmerin	AChE Is and GSK-3α/βIs	[100]
	deferasirox	AChE Is and metal chelators	[101]
	indole-3acetic acid	AChE/BuChE Is	[102]
	pulmonarin B	AChE/BuChE Is	[103]
	d-xylose, d-ribose, d-galactose	AChE/BuChE Is	[104]
	acridine	AChE/BuChE Is	[105]
	1,2,3-thiadiazole	AChE/BuChE Is	[106]
	ferulic acid	AChE/BuChE Is	[107]
	flavonoid quercetin	AChE/BuChE Is and metal chelators	[108]
	quinolone carboxylic acids	AChE/BuChE Is, M1R Is	[109]
Donepezil	hydroxyphenyl-benzimidazole	AChE Is and metal chelators	[110]
	hydroxybenzimidazole	AChE Is and metal chelators	[111]
	butylated hydroxytoluene hybrids	AChE Is, MAO-B Is, antioxidants	[112]
	trolox	AChE Is, MAO-B Is, metal chelators	[113]
	chromone	AChE Is, MAO-B Is	[114,115]
	chalcones	AChE/BuChE Is	[116]
	2-acetylphenol	AChE/BuChE Is, MAO-A/B Is, metal chelators	[117]
	deoxyvasicinone	AChE Is and BACE-1 Is	[118]
	introduction of amide bonds	AChE Is and BACE-1 Is	[119]
	conjugation of benzylpiperidine moiety benzimidazole or benzofuran	AChE Is, antioxidant, metal chelators	[120]
	melatonin	AChE/BuChE Is, antioxydants, metal chelators	[121]