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Coagulation cascade and fibrin formation by the intrinsic and extrinsic pathways. The heavy arrows show the extrinsic pathway, triggered by vascular injury and the expression of tissue factor. On the left side, by light arrows, the intrinsic pathway is shown. In the common pathway, thrombin is generated, which converts fibrinogen to fibrin (heavy arrows, too). Reprinted with permission from [13]. Copyright© 1991 American Chemical Society, Washington, DC, USA.
