Table 1.

ROTEM^® Assays. The left column lists the main tests with the corresponding descriptions of content, activation, coagulation determinants and usage on the right column.

EXTEM	• Contains tissue factor (thromboplastin) as activator • Reflects the extrinsic coagulation pathway • Depends on the activity of the coagulation factors X, VII, V, II, fibrinogen and platelets
INTEM	• Activated by ellagic acid and phospholipids • Imitates the contact activation, reflects the intrinsic coagulation pathway • Depends on the activity of the coagulation factors XII, XI, IX, VIII, X, V, II, fibrinogen and platelets
FIBTEM	• Contains the platelet inhibitor cytochalasin D • EXTEM-based • Clot formation is dependent on fibrinogen concentration and fibrin polymerization independent of platelets
APTEM	• Contains an antifibrinolytic drug (formerly aprotinin, currently tranexamic acid) • EXTEM-based • For in vitro simulation of antifibrinolytic therapy
HEPTEM	• Contains heparinase • INTEM-based • To asses heparin effect