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. 2020 Jul 28;15:1831–1838. doi: 10.2147/COPD.S247966

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© 2020 Kostikas et al.

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Proportion of patients achieving ECII with IND/GLY and SFC at (A) Week 4; and (B) Week 12. ECII definition 1: improvement in trough FEV₁ ≥100 mL and reduction in SGRQ-C total score ≥4; ECII definition 2: improvement in trough FEV₁ ≥100 mL and reduction in CAT total score ≥2; n, number of patients who achieved ECII at Week 4 or 12; N, number of patients corresponding to the respective treatment group included in the analysis.

Abbreviations: b.i.d., twice-daily; CAT, COPD assessment test; COPD, chronic obstructive pulmonary disease; ECII, Early Clinical Important Improvement; FEV₁, forced expiratory volume in 1 second; IND/GLY, indacaterol/glycopyrronium 110/50 μg o.d.; o.d. once-daily; OR, odds ratio; SFC, salmeterol/fluticasone 50/500 μg b.i.d.; SGRQ-C, St. George’s Respiratory Questionnaire for COPD.