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Structural modification strategy for development of peptidomimetics based on hot segments of FGF14 at its interface with Nav1.6. (A) The previously reported parental peptide Phe-Leu-Pro-Lys (FLPK) and its analogs, ZL177 (3) and ZL181 (4). (B) Structural modification strategy for development of chemical probes derived from the Glu-Tyr-Tyr-Val (EYYV) scaffold.
