Table 2.

The summary of described micro- and nanoparticles, fibers, and hydrogels for drug delivery based on a combination of PCL and its copolymers with different CDs.

Type of Drug Delivery System	Platform	Type of CD	Drug/Biomolecule	Release Medium	In Vitro/In Vivo Studies	Ref.
Microparticle	PCL	HP-β-CD	Diffractaic acid	pH 7.4	Vero cells	[61]
Nanoparticle	PCL	α-CD	Camptothecin/DOX	PBS	HepG2 cells	[63]
Hydrogel	PCL-b-PEG-b-PCL	β-CD	Indomethacin	PBS	Rat paws	[64]
Nanoparticle	PCL-b-PEG	β-CD	DOX	PBS	SKOV3 cells/HEK293T cells	[65]
Nanofiber	PCL	HP-β-CD	Sulfisoxazole	PBS	nd	[68]
Hydrogel	PCL-b-PEG	α-CD	Diclofenac	PBS	L-929 cells/HCEC cells/rabbit eyes	[69]
Hydrogel	(mPEG acetal- PCL-acetal-)3	α-CD	DOX hydrochloride	pH 5.0, pH 7.4	nd	[70]
Nanofiber	PCL	β-CD	α-Tocopherol	PBS	nd	[71]
Nanofiber	PCL	β-CD	Naproxen	PBS	nd	[72]
Nanofiber	PCL	β-CD	Ciprofloxacin	pH 7.2	nd	[73]
Nanofiber	PCL	γ-CD	Oxidoreductase	pH 7.5	Catalase enzyme/	[74]
Nanofiber	PCL	γ-CD	Oxidoreductase	pH 7.5	Laccase enzyme	[75]
Nanofiber	PCL	β-CD	Silver sulfadiazine	PBS	E. coli/Klebsiella pneumoniae/S. epidermidis/S. aureus	[76]
Nanofiber	PCL	β-CD	Tetracycline	PBS	Aggregatibacteractinomycetem comitans/Porphyromonas gingivalis	[77]
Nanoparticle	PCL-b-PEG	HP-β-CD	Docetaxel	PBS	MCF-7 cells	[78]
Nanoparticle	PCL-b-PEG	HP-β-CD	Paclitaxel/Cidofovir	pH 5.5	L929 cells,	[79]
Nanoparticle	PCL-b-PEG	β-CD	Paclitaxel	PBS	HepG2 cells	[80]
Nanoparticle	methoxy-PEG-b-PCL	Triacetyl-β-CD	Sepiapterin	PBS	nd	[81]
Nanoparticle	PCL-b-PEG	β-CD	DOX	pH 7.0–2.0	nd	[82]
Nanoparticle	Star-PCL-PEG	DMβ-CD	DOX	PBS/1,4-dithio- threitol solution	Skov cells/HEK293 T cells/ tumor-bearing mouse	[83]
Nanoparticle	Star-PCL-PEG	β-CD	DOX	PBS	A549 cells	[84]
Nanoparticle	Star-PCL-PEG	β-CD	DOX	PBS	HeLa cells	[85]
Hydrogel	PCL-b-PEG-b-PCL	γ-CD	Insulin	PBS	nd	[86]
Hydrogel	PCL-b-PEG-b-PCL	α-CD	B12 vitamin	PBS	nd	[87]
Hydrogel	PCL-b-PEG and poly(ethylene glycol)-b-poly(acrylic acid)	α-CD	DOX/Cisplatin	PBS	Human bladder carcinoma EJ cells	[88]
Hydrogel	methoxy PEG)-b-PCL-co-1,4,8-trioxa-[4.6]spiro-9-un-decanone	α-CD	Paclitaxel	PBS	HeLa cells/7703 cells	[89]
Hydrogel	mPEG–PCL–mPEG	α-CD	Erythropoietin	PBS	Rats heart muscle	[90]
Hydrogel	mPEG–b-PCL-b-poly[2-(dimethylamino) ethyl methacrylate	α-CD	DNA Polyplexes	PBS	COS7 cells	[91]
Hydrogel	PCL-b-PEG-b-PCL	γ-CD	Dexamethasone	PBS	nd	[92]
Nanoparticle	PCL-b-PEG	HP-β-CD	Docetaxel	PBS	HeLa cells	[93]