Table 3.
Summary of described hydrogels, micelles and nanoparticles for drug delivery based on combination of PEG and its copolymers with different CDs.
| Type of Drug Delivery System |
Platform | Type of CD | Drug | Release Medium |
In Vitro/In Vivo Studies |
Ref. |
|---|---|---|---|---|---|---|
| Micelles | PpIX-PEG | α-CDs | DOX | buffer (pH = 5.0 or pH = 7.4) |
HepG2 cells | [131] |
| Nanoparticles | Star-shaped polymers CD-g-TPGS with different TPGS |
β-CDs | DOX | PBS | MCF7 and ADR/MCF7 Cells/H22 sarcoma model |
[132] |
| Nanoparticles | Folic acid–poly-ethylene glycol–β-cyclodextrin (FA–PEG–β-CD) | β-CDs | DOX | PBS (pH = 5.0 or pH = 7.4) |
HepG2 cells | [133] |
| Nanoparticles | CDPF consisting of β-CD, PEG, and FA | β-CDs | DOX | PBS (pH 5.5, 6.8 and 7.4) |
MCF7 cells/ Male NCRNU nude mice |
[134] |
| Micelles | Ferrocene conjugated PEG (PEG-Fc) and β-CD-hydrazone-DOX | β-CDs | DOX | PBS (pH = 5.0 or pH = 7.4) |
HeLa cells | [135] |
| Nanoparticles | PEG-HPG-BM and FA-CD |
β-CDs | DOX | PBS (pH 5.3, 6.8 or 7.4) |
HeLa, HepG2, L929 cells | [136] |
| Nanoparticles | PEG-CD/AD/SF | β-CDs | DOX sorafenib |
PBS (pH = 5.0 or pH = 7.4) |
HepG2 cells | [137] |
| Nanospheres | DMPE-mPEG2000/γ-CD-C10 | γ-CDs | artemisinin | - | Intravenously injection to Wistar rats | [138] |
| Micelles | F127-CD conjugate | β-CDs | honokiol | PBS (pH = 7.4) |
Candida albicans as test strain | [139] |
| Nanoparticles | PEI-CD·PEG-AD·FA-AD | β-CDs | pDNA | - | FR-negative HEK293 and FR-positive KB cells | [140] |
| Nanoparticles | FA-PEG-GUG-β-CDE/DOX/ siPLK1 |
β-CDs | siRNA/DOX | PBS (pH 7.4) or citrate buffer (pH 5.5) | KB cells and BALB/c nu/nu mice | [141] |
| Micelles | P(Asp-co-AspGA)/P(Asp-co-AspPBA) | α-CDs | vancomycin | PBS (pH = 7.4) |
- | [142] |
| Nanoparticles | PNSC@APEG | β-CDs | 5-FU | PBS (pH = 7.4) |
NIH3T3 cell lines | [143] |
| Nanoparticles | PNS-SS-A CD-HPEG |
β-CDs | DOX | PBS (pH = 7.4) |
HeLa cells | [144] |
| Nanoparticles | β-CD-PEG capped ZnO |
β-CDs | Cur | PBS (pH 7.4) or acetate buffer (pH = 4.8) | MCF7 cells | [145] |
| Gel | β-CD/PEG | β-CDs | diclofenac | PBS (pH = 7.4)/pig skins |
- | [146] |
| Hydrogel | α-CD/PEO–PHB–PEO | α-CDs | dextran-FITC | PBS | - | [147] |
| Hydrogel | β-CD-NCO/ NH2-PEG-NH2 |
β-CDs | lysozyme, β-estradiol quinine |
PBS (pH = 7.2) |
- | [148] |
| Hydrogel | α-CD/ 4-arm-PEG |
α-CDs | brimonidine | PBS | - | [149] |
| Hydrogel | α-CD/ A-PEG-A T-PEG-T |
α-CDs | DOX | PBS (pH = 7.4) |
L929 cells/Sprague Dawley (SD) rats/Chinese Kunming (KM) female mice | [150] |
| Hydrogel | PEG-β-CyD/PEG-Ad | β-CDs | Tf-AF647 | PBS | HeLa cells | [151] |
| Hydrogel | β-CD/ Pluronic® 127 |
β-CDs | curcumin | PBS (pH = 7.4)/acidic buffer solution (pH 1.2) |
HeLa, MCF-7 and L929 cells |
[152] |
| Hydrogel | α-CD/ NPOD-PEG |
α-CDs | DOX | PBS (pH 7.4) or acetate buffer (pH 5.0) | A549 cells | [153] |