Table 2.

Physicochemical properties and PK parameters of the active GAL-CU hybrids.

Parameter	4a	4b	4e	4f	8b	GAL
Mw	459.58	489.60	503.59	473.60	523.62	287.35
pKa	7.78	7.77	7.77	7.77	6.58	7.92
logP	4.53 ± 0.8	4.48 ± 0.81	4.64 ± 0.85	4.99 ± 0.80	4.9 ± 0.85	1.75
logD7.4	3.97	3.92	4.09	4.43	4.83	1.12
PSA	59.00	68.23	77.46	59.00	68.23	41.93
HBD	1	1	1	1	1	1
HBA	5	6	7	5	6	4
fBH+	0.71	0.70	0.70	0.70	0.13	0.77
VDssL/kg	4.71	4.95	5.88	5.31	1.85	2.30 a
fu	0.082	0.085	0.094	0.078	0.029	0.83 a
CL, L/h/kg	0.466	0.412	0.388	0.445	0.305	0.336 a
t1/2, h	7.01	8.32	10.51	8.28	4.19	4.74

^a [54].