Table 2.
Antimicrobial activity of tested compounds, prepared directly and stored for two weeks, shown as minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). Gentamicin, amoxicillin and amphotericin B used as antibacterial and antifungal reference substances, respectively; (-) not tested.
| Microorganism | MIC/MBC (mM) | MIC = MBC (mM) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| AlaSal | Co(II) Alone | Co(II)–AlaSal Complexes | Gentamicin | Amphotericin B | Amoxicillin | ||||
| MIC | MBC | MIC | MBC | MIC | MBC | ||||
| Gram-negative bacteria | |||||||||
|
Pseudomonas aeruginosa ATCC 27853 |
1.82 | 1.82 | 0.91 | 1.82 | 1.82 | 1.82 | <0.008 | - | - |
|
Escherichia coli ATCC 25922 |
7.30 | >7.30 | 1.82 | 1.82 | 7.30 | >7.30 | <0.004 | - | - |
|
Helicobacter pylori CCUC 17874 |
7.30 | >7.30 | 1.82 | >7.30 | 3.65 | 3.65 | - | - | <0.001 |
|
Helicobacter pylori ATCC 700392 |
7.30 | >7.30 | 1.82 | >7.30 | 3.65 | 3.65 | - | - | <0.001 |
| Gram-positive bacteria | |||||||||
|
Enterococcus faecalis ATCC 29212 |
7.30 | >7.30 | 1.82 | 1.82 | 1.82 | 3.65 | <0.26 | - | - |
|
Staphylococcus aureus ATCC 29213 |
7.30 | >7.30 | 0.91 | 0.91 | 1.82 | 3.65 | <0.002 | - | - |
|
Staphylococcus aureus ATCC 6538 |
7.30 | >7.30 | 0.91 | 0.91 | 1.82 | 3.65 | <0.002 | - | - |
| Staphylococcus epidermidis ATCC 12228 | 7.30 | >7.30 | 0.91 | 0.91 | 1.82 | 3.65 | <0.002 | - | - |
| Fungi | |||||||||
|
Candida albicans ATTC 10231 |
3.65 | >7.30 | 0.23 | 3.65 | 1.82 | 3.65 | - | <0.001 | - |
|
Candida glabrata ATCC 2001 |
3.65 | >7.30 | 0.23 | 3.65 | 1.82 | 3.65 | - | <0.001 | - |
|
Candida parapsilosis ATCC 22019 |
3.65 | >7.30 | 0.23 | 7.30 | 1.82 | 3.65 | - | <0.001 | - |