Table 2.

Inclusion and exclusion criteria

Criteria	Requirement	Screening
Inclusion criteria
Diagnosis	Clinically definite PMS	Telephone
Age	25–65 years	Telephone
Ambulation	NOT wheelchair dependent (EDSS < 7)	Telephone
Processing speed impairment	SDMT Total Score ≥ 1.282 SD below published normative data (10th percentile)	In-person
Exclusion criteria
Substance abuse	Use of illicit drugs, PCP, LSD, Stimulants, Amphetamines, Barbiturates, etc. (Cannabis use was acceptable)	Telephone
Neurological history	A history of central nervous system disease other than PMS (e.g., stroke, Parkinson´s disease, traumatic brain injury)	Telephone
Severe mental illness	Psychotic symptoms, bipolar disorder, schizophrenia	Telephone
Medication use	Steroids use within the past 3 months	Telephone
Transport	Unable or unwilling to travel to the center for testing and training or requiring transportation by ambulance	Telephone
Medical contraindication	No medical clearance from family doctor	Telephone
Current exercise routine	Currently performing medium-to-high-intensity workouts according to the Exercise History Screening Questionnaire (GLTEQ score < 23)	Telephone
Visual acuity	Corrected near vision of at least 20/70 (to see the test materials). Severe nystagmus according to neurologist ratings	In-person
Depression	Beck Depression Inventory II Score ≥ 29	In-person
Language comprehension	Token Test Score ≥ 29	In-person
MRI compatibility (MRI sites only)	Failing the standard MRI screening form for MRI Compatibility	In-person