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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Mol Carcinog. 2020 May 11;59(8):955–966. doi: 10.1002/mc.23214

Figure 6:

Figure 6:

Effect of class I HDAC knockdown on migration and proliferation ability of prostate cancer cells. (A) Wound healing assay was performed in class I HDAC silenced LNCaP cells. Images were taken before (0 h) and after wound closure (24, 48, 72h). The results were expressed as the percentage of the remaining area determined by normalizing the area of wound after 24 h or 48 h (as indicated) to the initial wound area at 0 h (set to 100%). Each bar represents the mean of 5 fields measured ± SD. Two‐tailed Student’s t‐test was used to compare sh-HDAC2 and sh-HDAC3 groups and control. **P < 0.001 versus control. (B) Doubling time was assessed in LNCaP cells silenced for Class I HDACs at 24, 48 and 72h after plating 25,000 cells/well and allowed to attach overnight. The changes in doubling time were expressed as percentage. Two‐tailed Student’s t‐test was used to compare various sh-HDAC1–8 groups with control. ***P < 0.0001 versus control.