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Schematic model demonstrating the role of class I HDACs on maspin inhibition. Class I HDACs binds to the maspin promoter along with the transcription factor complex. Silencing of class I HDACs lead to increase in p53 enrichment and its binding to the maspin promoter along with acetylation of Histone H3/H4 in prostate cancer LNCaP cells. HDAC, histone deacetylases; HAT, histone acetyltransferases.
