Table 3.
Lipid profiles in the serum and liver tissues after the chronic administration of melatonin for 8 weeks.
| VC | PC | MEL10 | MEL20 | MEL50 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TG (mg/dL) | 51.2 | ± | 5.8 | 43.2 | ± | 4.9 | 36.7 | ± | 2.7 | 32.7 | ± | 3.9 | 38.7 | ± | 6.4 |
| TC (mg/dL) | 59.7 | ± | 5.6 b | 86.3 | ± | 7.1 a | 67.3 | ± | 5.3 b | 64.3 | ± | 4.2 b | 62.0 | ± | 8.5 b |
| HDL-C (mg/dL) | 10.3 | ± | 0.8 c | 19.0 | ± | 1.1 a | 14.5 | ± | 1.4 b | 14.3 | ± | 0.8 b | 12.8 | ± | 1.5 b,c |
| LDL-C (mg/dL) | 5.00 | ± | 0.52 | 5.50 | ± | 0.50 | 4.83 | ± | 0.48 | 4.67 | ± | 0.33 | 4.00 | ± | 0.37 |
| Hepatic TC (mg/g liver) | 2.46 | ± | 0.15 | 2.94 | ± | 0.36 | 2.98 | ± | 0.07 | 2.71 | ± | 0.27 | 2.64 | ± | 0.15 |
| Hepatic TG (mg/g liver) | 11.2 | ± | 1.6 | 16.0 | ± | 2.0 | 14.2 | ± | 1.1 | 11.2 | ± | 0.6 | 12.7 | ± | 1.6 |
Values are the mean ± SEM (n = 6). a,b,c Values with different superscripts significantly differ (p < 0.05). TG, triglyceride; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol. VC, vehicle control; PC, positive control; MEL10, MEL20, and MEL50 are 10, 20, and 50 mg melatonin/kg body weight, respectively.