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Interaction of HCQ with ACE2 viral receptor protein (a). Best docking site of HCQ within coronavirus spike protein central core region with ACE value −293.32 (b–d). Best docking site of TFDG at the hinge region of virus–receptor attachment site opening with ACE value −465.17 (g). TFDG forms rigid bonds with ASN978, THR549, ASN856, THR572, THR573 and ASP578 near the ARG983 (h)
