Table 2.
GRADE evidence profile of COVID‐19 studies
| Out come | No. of participants | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Quality of evidence (Grade) | Relative effect | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Total no. | Intervention | Control | ||||||||
| Mortality | 5444 | 5169 | 285 | Yes | No | No | No | None | Low ⊕⊕⊝⊝ | OR 0.44 (95% CI, 0.25 to 0.77) |
| Clinical improvement | 259 | 130 | 129 | Yes | No | No | Yes | None | Very low ⊕⊝⊝⊝ | OR 2.06 (95% CI, 0.8 to 4.9) |
| Viral Clearance | 144 | 68 | 76 | Yes | No | No | No | None | Low ⊕⊕⊝⊝ | OR 11.29 (95% CI, 4.9 to 25.9) |
Abbreviations: CI, confidence interval; COVID‐19, coronavirus disease 2019; GRADE, Grading of Recommendations Assessment, Development, and Evaluation; MD, mean difference; OR, odds ratio.