Table 2.
Weighted mean differences in admission laboratory values comparing patients with severe disease to those with non‐severe disease
| Laboratory marker | Studies, n | Patients, n | Weighted mean difference (95% CI) | I 2 (%) | P value |
|---|---|---|---|---|---|
| Complete blood count | |||||
| Hemoglobin (Hb, g/L) | 21 | 3819 | −3.91 (−6.47, −1.35) | 62.4 | .003NS |
| White blood cell count (WBC, 109/L) | 40 | 6705 | 1.23 (0.85, 1.60) | 77.7 | .000 |
| Absolute neutrophil count (ANC, 109/L) | 35 | 4930 | 1.49 (0.96, 2.01) | 92.3 | .000 |
| Absolute lymphocyte count (ALC, 109/L) | 44 | 9873 | −0.30 (−0.37, −0.24) | 89 | .000 |
| Platelet count (PLT, 109/L) | 27 | 4515 | −16.69 (−35.35, 1.96) | 92.6 | .080NS |
| Inflammatory markers | |||||
| C‐reactive protein (CRP, mg/L) | 35 | 7660 | 39.91 (33.17, 46.64) | 84.5 | .000 |
| Erythrocyte sedimentation rate (ESR, mm/h) | 11 | 2653 | 6.84 (3.37, 10.31) | 69.4 | .000 |
| Ferritin (ng/mL) | 6 | 3508 | 432.13 (281.41, 582.85) | 72.0 | .000 |
| Interleukin‐6 (IL‐6, pg/mL) | 16 | 2526 | 12.25 (7.00, 17.50) | 95.8 | .000 |
| Interleukin‐10 (IL‐10, pg/mL) | 7 | 1136 | 1.86 (1.07, 2.64) | 91.3 | .000 |
| Procalcitonin (ng/mL) | 22 | 6481 | 0.08 (0.05, 0.11) | 94.2 | .000 |
| Liver function tests | |||||
| Albumin (g/L) | 18 | 3169 | −4.36 (−5.08, −3.64) | 75.1 | .000 |
| Bilirubin (Bili, µM) | 20 | 3025 | 1.93 (1.28, 2.57) | 42.9 | .000 |
| Prothrombin time (PT, s) | 17 | 2304 | 0.44 (0.24, 0.64) | 78.0 | .000 |
| Renal function tests | |||||
| Creatinine (Cr, µM) | 32 | 7580 | 7.34 (2.59, 12.10) | 91.7 | .002NS |
| Blood urea nitrogen (BUN, mM) | 21 | 3797 | 1.28 (0.82, 1.74) | 88.2 | .000 |
| Coagulation markers | |||||
| Activated partial thromboplastin time (APTT, s) | 11 | 1288 | 0.59 (−1.22, 2.39) | 83.9 | .523NS |
| D‐dimer (mg/L) | 30 | 6950 | 0.67 (0.52, 0.82) | 92.7 | .000 |
| Markers of tissue damage | |||||
| Lactate dehydrogenase (LDH, U/L) | 27 | 3791 | 120.31 (93.50, 147.12) | 89.3 | .000 |
| Creatine kinase (CK, U/L) | 15 | 2585 | 45.33 (18.60, 72.07) | 93.5 | .001 |
| High sensitivity troponin I (hsTropI, pg/mL) | 6 | 1223 | 11.07 (3.64, 18.50) | 73.7 | .004NS |
| Troponin I (TropI, ng/mL) | 3 | 3222 | 0.04 (−0.01, 0.09) | 87.8 | .134NS |
| Creatine kinase myocardial band (CKMB, U/L) | 8 | 1639 | 2.44 (0.78, 4.11) | 90.9 | .004NS |
| Alanine aminotransferase (ALT, U/L) | 31 | 6854 | 6.25 (3.09, 9.42) | 86.6 | .000 |
| Aspartate aminotransferase (AST, U/L) | 30 | 6746 | 8.52 (4.98, 12.06) | 91.1 | .000 |
| Alkaline phosphatase (ALP, U/L) | 6 | 723 | −1.50 (−6.41, 3.41) | 28.7 | .549NS |
| Gamma glutamyl transferase (GGT, U/L) | 6 | 723 | 5.01 (−3.16, 13.17) | 48.0 | .230NS |
I 2 statistic – Describes the percentage of variation across studies estimated to be due to heterogeneity.
NS
Denotes nonsignificant P values. Bonferroni corrected significance levels is .002.