FIGURE 9.

(a) Main protease interacting with the compound 13b at the binding cavity present between the two domains of Mpro. (b) The structure of the docking complexes of GRP78 represented in green and COVID‐19 spike glycoprotein represented in yellow. (c) The crystal structure of COVID‐19 Mpro in complex with N3 inhibitor. (d) Surface of target Mpro. (e) Binding cavity of Mpro and its key residues interacting with N3 inhibitor. (f) Zoomed in view of the interaction involving C–S covalent bond between the N3 inhibitor and the target Mpro. Source: This figure is adapted with permission from Zhang et al. (2020); Ibrahim, Abdelmalek, Elshahat, and Elfiky (2020); and Jin et al. (2020) [Color figure can be viewed at wileyonlinelibrary.com]