TABLE 4.
Independent risk factors for prolonged viral shedding
| Factors | Unadjusted | Adjusted | ||
|---|---|---|---|---|
| HR | P value | HR | P value | |
| Illness severity status | 0.004 | 0.688 | ||
| Normal | 1 | 1 | ||
| Severe | 0.608 (0.413‐0.897) | 0.012 | 1.117 (0.716‐1.743) | 0.626 |
| Critical | 0.503 (0.294‐0.863) | 0.013 | 1.311 (0.683‐2.517) | 0.415 |
| Radiographic extent | <0.001 | 0.080 | ||
| 1 | 1 | 1 | ||
| 2 | 0.606 (0.290‐1.265) | 0.182 | 0.649 (0.306‐1.381) | 0.262 |
| 3 | 0.915 (0.453‐1.851) | 0.806 | 0.856 (0.419‐1.747) | 0.669 |
| 4 | 0.351 (0.176‐0.701) | 0.003 | 0.407 (0.198‐0.835) | 0.014 |
| 5 | 0.394 (0.214‐0.725) | 0.003 | 0.608 (0.306‐1.210) | 0.156 |
| Lymphocyte count | 1.565 (1.142‐2.145) | 0.005 | 1.226 (0.838‐1.794) | 0.295 |
| Hs‐CRP | 0.995 (0.992‐0.999) | 0.014 | 1.001 (0.996‐1.005) | 0.682 |
| Albumin | 1.036 (1.008‐1.064) | 0.012 | 0.998 (0.958‐1.041) | 0.939 |
| Time from illness onset to admission | 0.877 (0.838‐0.917) | <0.001 | 0.829 (0.784‐0.877) | <0.001 |
| Antibiotics | 0.499 (0.352‐0.706) | <0.001 | 0.779 (0.499‐1.216) | 0.272 |
| Corticosteroid | 0.554 (0.407‐0.754) | <0.001 | 0.496 (0.318‐0.773) | 0.002 |
| Arbidol | 2.720 (1.423‐5.202) | 0.002 | 2.605 (1.280‐5.302) | 0.008 |
| Oseltamivir | 0.527 (0.385‐0.722) | <0.001 | 0.416 (0.279‐0.620) | <0.001 |
| Immunoglobulin | 0.461 (0.307‐0.692) | <0.001 | 0.802 (0.487‐1.318) | 0.384 |
Abbreviation: Hs‐CRP, high sensitive C‐reaction protein.