Table 1.
Summary of case reports with galantamine and rivastigmine.
| Case | Age | Sex | AChEi | HR | QTc (ms) | TdP | Medical history | Drug history | Intervention | Naranjo | UMC-WHO |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Fisher and Davis46 | 85 | M | Galantamine (8 mg) | 83 | 503 | N | CAD, hypertension, osteoarthritis, hiatus hernia, BPH surgery Normal electrolytes |
Irbesartan, clopidogrel, simvastatin, pantoprazole, ergocalciferol, calcium carbonate, acetaminophen | Galantamine and irbesartan removed | Probable | Probable/likely |
| Nelson and Buchanon47 | 47 | M | Galantamine (12 mg) | 70 | 518 | N | Schizophrenia, diabetes, hypertension and hyperlipidaemia Normal electrolytes |
Aripiprazole, quetiapine, lithium, benztropine, trazadone, docusate, enalapril, insulin, metoprolol, ranitidine, simvastatin | Galantamine stopped immediately | Probable | Probable/likely |
| Walsh and Dourish44 | 78 | M | Rivastigmine | 60 | 477 | N | AD, MI, borderline hypokalaemia Normal electrolytes except for [K+]=3.4 mM |
Diltiazem, citalopram, furosemide, aspirin and ranitidine | Rivastigmine stopped | Possible | Probable/likely |
Summary information on each case is given under each of the subheading categories shown. Note that only the Fisher and Davis report stated the correction formula used (Bazett’s) to obtain QTc interval value shown.
AChEi, acetylcholinesterase inhibitor; AD, Alzheimer’s disease; BPH, benign prostatic hyperplasia; CAD, coronary artery disease; HR, heart rate; MI, myocardial infarction; TdP, Torsades de Pointes.