Table 2.
Summary of information on case reports with donepezil.
| Case | Age | Sex | AChEi | HR | QTc (ms) | TdP | Medical history | Drug history | Intervention | Naranjo | WHO-UMC |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Leitch et al.49 | 76 | F | Donepezil (10 mg) | 42 | 590–777 | Y | Depression, AD Normal electrolytes |
Omeprazole, escitalopram, propranolol |
IV Mg and isoprenaline, temp cardiac pacing | Possible | Possible |
| Tanaka et al.52 | 90 | M | Donepezil (10 mg) | 36 | 398 | N | AD Normal (K+) (other electrolytes not mentioned) |
donepezil stopped, orciprenaline started | Probable | Probable/likely | |
| Tanaka et al.52 | 87 | F | Donepezil (5 mg) | 40 | 594 | Y | Hypertension, AF, AD and bradycardia Normal (K+) (other electrolytes not mentioned) |
Cilostazol, amlodipine, spironolactone, warfarin | donepezil stopped, orciprenaline started | Possible | Possible |
| Takaya et al.53 | 83 | F | Donepezil (5 mg) | 54 | 645 | Y | Hypertension, AD, AF, MI and diabetes Hypokalaemia [(K+)=3.3 mM]. |
Bisoprolol | Donepezil stopped, IV Mg, K and lidocaine, isoprenaline injection | Possible | Possible |
| Kitt et al.54 | 80 | F | Donepezil (10 mg) | 85 | 490 | Y | Cerebrovascular disease, mixed vascular and AD, AF (permanent pacemaker) and hypertension Normal electrolytes |
Bumetanide, perindopril, lansoprazole, atorvastatin, diltiazem M/R, fluoxetine | IV Mg/fluids, donepezil stopped, fluoxetine decreased, defibrillator | Probable | Probable/likely |
| Gurbuz et al.55 | 84 | F | Donepezil (10 mg) | 65 | 624 | Y | CAD, AD and hypertension Normal electrolytes |
Ramipril, aspirin | IV K and Mg and stopped donepezil | Probable | Certain |
| Pourmand et al.56 | 84 | M | Donepezil (35 mg) | 70 | 502 | N | AD, hypertension, stroke, BPH Normal electrolytes |
Donepezil overdose | dose of atropine and stopped donepezil | Probable | Certain |
| Shinozaki33 | 80 | F | Donepezil (5 mg) | 78 | 480 | N | AD, hypertension, hypercholesterolaemia, osteoporosis Normal electrolytes |
Benidipine, atorvastatin, vitamin D, risedronate | Changed benidipine to amlodipine | Possible | Possible |
| Jackson and Stowe57 | 83 | F | Donepezil (10 mg) | 638 | N | AD, unwitnessed syncope, history of falls, hip fracture, hypertension. Normal electrolytes |
Bendroflumethiazide, simvastatin |
Donepezil stopped | Probable | Probable/Likely | |
| Vogel et al.58 | 26 | F | Donepezil (20 mg) | 70–81 | 463–528 | N | Major depressive disorder, dysarthria, TBI, seizures, hemiplegia, GERD, tachycardia. Normal [K+] No [Mg2+] data |
Quetiapine, metoprolol, PEG-3350, cephalexin, diphenhydramine | Donepezil stopped | Probable | Probable/Likely |
Summary information on each case is given under each of the subheading categories shown. Note that only the Gurbuz et al. report stated the correction formula used (Bazett’s) to obtain QTc interval value shown.
AChEi, acetylcholinesterase inhibitor; AD, Alzheimer’s disease; AF, atrial fibrillation; BPH, benign prostatic hyperplasia; CAD, coronary artery disease; HR, heart rate; MI, myocardial infarction; TdP, Torsades de Pointes.