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. 2020 Jul 30;20(4):71. doi: 10.3892/ol.2020.11932

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Copyright: © Lei et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Digitoxin shows cytotoxicity towards HepG2/ADM cells. (A) HepG2/ADM cells were treated with 78 compounds at 0.1 µM for 24 h and the viability was measured using the MTT assay. Digitoxin (No. 63) was identified as the most cytotoxic compound towards HepG2/ADM cells among the different compounds, indicated by the red color. *P<0.05 vs. the control group. (B) Chemical structure of digitoxin. (C) HepG2/ADM cells were treated with digitoxin at different concentrations for 24, 48 or 72 h and the viability was measured using the MTT assay. Digitoxin exerted an anti-HCC effect on HepG2/ADM cells in a dose- and time-dependent manner.