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Applications of CRISPR and transposon mutagenesis for in vivo cancer screens. Cancer is typically genetically and phenotypically heterogeneous, and immune cells in the microenvironment play a pivotal role in oncogenesis. Key areas for investigation of cancer by in vivo screens include genetic mechanisms of tumor heterogeneity, metastasis, immune evasion, and resistance to treatment. “T” = transposon mutagenesis; “C” = CRISPR
