Fig. 2.

CircZFR silencing suppressed BC progression in vitro and in vivo. a, b qRT-PCR for circZFR expression in MCF7 and BT-549 cell lines transduced with sh-NC, sh-circZFR#1, sh-circZFR#2 or sh-circZFR#3. CCK-8 assay for cell viability (c), colony formation assay for cell colony formation (d, e), flow cytometry for cell apoptosis (f, g) in sh-NC-infected or sh-circZFR-transduced MCF7 and BT-549 cell lines. h, i sh-NC-infected or sh-circZFR-transduced BT-549 cell line was subcutaneously injected into the nude mice (n = 6 per group), followed by the measurement of tumor volume and weight and the capture of representative pictures. *P < 0.05