Table 1.
Baseline characteristics of AIP patients at diagnosis and clinical presentation.
| Overall | Type 1 AIP§ (n = 106) | Type 2 AIP§ (n = 48) | p-value | NOS-AIP§ (n = 19) | |
|---|---|---|---|---|---|
| Male (%) | 108 (62.4) | 71 (66.9) | 26 (54.2) | 0.13 | 11 |
| Age at diagnosis (median) | 61 | 62.5 | 48 | <0.001 | 62 |
| BMI* at diagnosis (median) | 23.5 | 23.8 | 23.5 | 0.9 | 28.8 |
| Comorbidities | |||||
| Cardiovascular | 56 (32.4) | 40 (37.7) | 13 (27.1) | 0.2 | 3 (15.8) |
| Diabetes | 18 (10.4) | 13 (12.3) | 3 (6.2) | 0.25 | 2 (10.5) |
| Cancers | 9 (5.2) | 6 (5.7) | 1 (2.1) | 0.3 | 2 (10.5) |
| Pulmonary | 16 (9.2) | 12 (11.3) | 3 (6.2) | 0.32 | 1 (5.3) |
| Rheumatological | 14 (8.1) | 7 (6.6) | 5 (10.4) | 0.41 | 2 (10.5) |
| Gastrointestinal | 28 (16.2) | 8 (7.5) | 17 (35.4) | <0.001 | 3 (15.8) |
| Autoimmune | 15 (8.7) | 11 (10.4) | 3 (6.2) | 0.4 | 1 (5.3) |
| Prostatic | 12 (6.9) | 8 (7.5) | 3 (6.2) | 0.4 | 1 (5.3) |
| Other organ involvement in type 1 AIP§ | |||||
| Overall | 61 (57.5) | ||||
| Biliary ducts | 42 (39.6) | ||||
| Salivary glands | 8 (7.5) | ||||
| Kidneys | 12 (11.3) | ||||
| Lymph nodes | 10 (9.4) | ||||
| Retroperitoneal fibrosis | 2 (1.9) | ||||
| Lungs | 8 (7.5) | ||||
| Other | 7 (6.6) | ||||
| IBD# | 21 (12.1) | 2 (1.9) | 13 (27.1) | <0.001 | 2 (10.5) |
| Symptoms | |||||
| Dark urine | 30 (17.3) | 22 (20.7) | 7 (14.6) | 0.37 | 1 (5.3) |
| Pale faeces | 28 (16.2) | 21 (19.8) | 6 (12.5) | 0.27 | 1 (5.3) |
| Jaundice | 70 (40.5) | 52 (49.0) | 12 (25.0) | 0.005 | 6 (31.6) |
| Acute pancreatitis | 37 (21.4) | 21 (19.8) | 12 (25.0) | 0.47 | 4 (21) |
| Epigastric pain | 51 (29.5) | 26 (24.5) | 15 (31.25) | 0.38 | 10 (5.3) |
| Radiating epigastric pain | 27 (15.6) | 12 (11.3) | 12 (25.0) | 0.03 | 3 (15.8) |
| Lumbar pain | 13 (7.5) | 7 (6.6) | 4 (8.3) | 0.7 | 2 (10.5) |
| Nausea | 14 (8.1) | 10 (9.4) | 3 (6.25) | 0.51 | 1 (5.3) |
| Astenia | 25 (14.4) | 16 (15.1) | 8 (16.7) | 0.8 | 1 (5.3) |
| Anorexia | 21 (12.1) | 16 (15.1) | 5 (10.4) | 0.43 | 0 |
| Weight loss | 40 (23.1) | 26 (24.5) | 10 (20.8) | 0.62 | 4 (21) |
| Analgesics | 71 (41) | 33 (31.1) | 26 (54.2) | 0.006 | 12 (63.2) |
§AIP: autoimmune pancreatitis; °NOS: not otherwise specified; *BMI: body mass index; #IBD: inflammatory bowel disease.