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. 2020 Jul 29;2(8):491–495. doi: 10.1002/acr2.11164

Figure 2.

Figure 2

Anticipated hydroxychloroquine (HCQ) concentrations for options 1, 2, and 3. Monte Carlo simulations using parameters identified in patients with rheumatoid arthritis (8) and a blood HCQ half‐life of 43 hours were performed for both scenarios. A, Mean blood HCQ concentrations for 400 mg/d for 10 days (blue), alternating 400 and 200 mg every other day for 14 days (grey), and 200 mg/d for 20 days (red). Ten‐fold inflated model parameter variance simulations for 400 mg/d for 10 days (B), alternating 400 and 200 mg every other day for 14 days (C), and 200 mg/d for 20 days (D). For visual clarity, 30 simulations are shown in panels B, C, and D, but the data in the text are from 1000 simulations. E, Fraction of the 1000 simulations wherein blood HCQ concentration greater than 700 ng/ml for each day for each scenario. dieb. alt. = deibus alternis (every other day).