Table 2.
Regression results using each volume of cortical and subcortical structures as the predicted variable (N = 1350).
| Age | Sex | Ethnicity | Education | ICV | Model | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| b | p | b | p | b | p | b | p | b | p | R2 | |
| Brain volume | −0.30 | 1.1E-84 | −0.03 | 1.1E-01 | −0.32 | 1.0E-66 | 0.00 | 9.6E-01 | 0.87 | 1.9E-297 | 0.752 |
| Cortical volumes | |||||||||||
| Frontal | −0.18 | 1.4E-22 | 0.00 | 8.7E-01 | −0.43 | 8.3E-73 | 0.02 | 5.2E-01 | 0.73 | 1.5E-163 | 0.589 |
| Temporal | −0.31 | 2.5E-57 | 0.02 | 3.9E-01 | −0.46 | 1.3E-83 | −0.02 | 3.7E-01 | 0.65 | 6.2E-141 | 0.597 |
| Parietal | −0.18 | 8.1E-24 | −0.05 | 2.1E-02 | −0.62 | 9.1E-142 | 0.02 | 3.5E-01 | 0.63 | 1.2E-137 | 0.609 |
| Occipital | −0.25 | 2.4E-32 | 0.03 | 2.5E-01 | −0.47 | 2.9E-68 | 0.02 | 4.9E-01 | 0.53 | 5.2E-80 | 0.468 |
| Cingulate | −0.14 | 8.2E-11 | 0.01 | 6.9E-01 | −0.38 | 1.8E-45 | 0.04 | 1.6E-01 | 0.64 | 5.9E-108 | 0.459 |
| Insular | −0.06 | 8.8E-03 | 0.07 | 1.8E-02 | −0.33 | 5.1E-35 | 0.00 | 9.5E-01 | 0.62 | 4.2E-98 | 0.437 |
| Subcortical volumes | |||||||||||
| Ventricle | 0.34 | 2.7E-50 | −0.04 | 2.1E-01 | 0.08 | 1.6E-03 | −0.02 | 5.2E-01 | 0.51 | 2.8E-68 | 0.420 |
| Thalamus | −0.18 | 3.7E-15 | −0.05 | 1.1E-01 | −0.49 | 8.9E-65 | 0.01 | 6.7E-01 | 0.49 | 2.4E-62 | 0.386 |
| Putamen | −0.25 | 2.8E-22 | −0.03 | 3.0E-01 | −0.01 | 7.4E-01 | 0.04 | 2.3E-01 | 0.41 | 3.4E-35 | 0.203 |
| Hippocampus | −0.42 | 1.1E-67 | −0.01 | 7.8E-01 | −0.38 | 2.7E-41 | 0.03 | 3.0E-01 | 0.27 | 3.4E-21 | 0.371 |
| Caudate | −0.06 | 1.6E-02 | −0.12 | 1.9E-04 | 0.09 | 1.8E-03 | 0.02 | 4.9E-01 | 0.52 | 1.2E-56 | 0.243 |
| Amygdala | −0.32 | 7.4E-38 | 0.12 | 1.7E-04 | −0.37 | 4.2E-35 | 0.03 | 3.6E-01 | 0.27 | 8.0E-19 | 0.305 |
| Pallidus | 0.04 | 1.0E-01 | −0.01 | 6.8E-01 | −0.12 | 8.8E-05 | −0.03 | 4.4E-01 | 0.43 | 2.5E-36 | 0.164 |
| Accumbens | −0.33 | 3.5E-33 | 0.06 | 1.0E-01 | 0.09 | 5.0E-03 | 0.07 | 4.5E-02 | 0.14 | 3.4E-05 | 0.144 |
Age, sex, ethnicity, education, and intracranial volume (ICV) were used as predictors in the regression analyses. p indicates statistical significance. b indicates the standardized regression coefficient that is presented in italic at the 95% significance level, or in bold after Bonferroni correction.