Table 3.
The Top Five Gene Ontology and KEGG Pathway Enrichment of DEGs, Analysed by DAVID
| ID | Term | Count | P value | Genes |
|---|---|---|---|---|
| Biological Process | ||||
| GO:0001731 | Formation of translation preinitiation complex | 3 | 0.006970337 | EIF3C, EIF4B, EIF3E |
| GO:0032869 | Cellular response to insulin stimulus | 4 | 0.008691289 | SP1, XBP1, APRT, PIK3R2 |
| GO:0014065 | Phosphatidylinositol 3-kinase signaling | 3 | 0.009534075 | XBP1, GATA3, PIK3R2 |
| GO:0006446 | Regulation of translational initiation | 3 | 0.016576226 | EIF3C, EIF4B, EIF3E |
| GO:0009267 | Cellular response to starvation | 3 | 0.027361724 | MAX, PPM1D, KIAA1324 |
| Cellular component | ||||
| GO:0000790 | Nuclear chromatin | 6 | 0.003712494 | SP1, NCOA3, SMARCD2, RXRA, GATA3, ESR1 |
| GO:0005829 | Cytosol | 29 | 0.006647911 | RHPN1, PREX1, STARD10, RPS6KB1, BLOC1S6, EIF3C, HOOK2, XBP1, EIF3E, FRAT1, AANAT, FRAT2, PABPC1, DHTKD1, PSMD6, PIK3R2, ABCA12, MATK, PARD6B, FBP1, LARP4B, APRT, EIF4B, TRIM37, MKS1, ALOX15, MVK, SIAH2, PDZD3 |
| GO:0005654 | Nucleoplasm | 25 | 0.009918189 | RAD51C, RPS6KB1, BLOC1S6, MAX, SMARCD2, XBP1, EIF3E, GATA3, NR2F6, PATZ1, PSMD6, SCAMP1, RXRA, ESR1, SPPL2B, BRIP1, TEAD2, ECSIT, APRT, RNF44, NCOA3, SP1, TUBD1, RFX1, SIAH2 |
| Molecular function | ||||
| GO:0005515 | Protein binding | 62 | 0.007869723 | RAD51C, SEPT2, PREX1, RPS6KB1, VPS37C, HOOK2, MAX, SMARCD2, GATA3, NR2F6, FRAT1, PSMD6, RMND1, DSCAM, MATK, SCAMP1, MRPL4, VANGL1, RXRA, ESR1, FBP1, ECSIT, TRIM37, MKS1, PPM1D, ALOX15, NCOA3, MVK, SIAH2, ITGA2B, GATC, RHPN1, STARD10, EIF3C, BLOC1S6, FBXW9, XBP1, EIF3E, AANAT, LETMD1, TFF1, PABPC1, APPBP2, TMEM183A, USP32, ABCA12, PIK3R2, PARD6B, SPTSSB, SPPL2B, BRIP1, TEAD2, NPY1R, LARP4B, CYB561, EIF4B, PLEKHF2, SP1, WDR25, RFX1, DYM, PDZD3 |
| GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | 3 | 0.017092174 | RXRA, NR2F6, ESR1 |
| GO:0001046 | Core promoter sequence-specific DNA binding | 3 | 0.02389184 | SP1, GATA3, ESR1 |
| GO:0043565 | Sequence-specific DNA binding | 8 | 0.025500996 | MAX, IRX5, SP1, XBP1, RXRA, NR2F6, SPDEF, ESR1 |
| GO:0003707 | Steroid hormone receptor activity | 3 | 0.038898918 | RXRA, NR2F6, ESR1 |
| KEGG pathway enrichment analysis | ||||
| hsa03013 | RNA transport | 6 | 0.005016166 | EIF3C, EIF4B, EIF3E, PABPC3, PABPC1, NUP210L |
| hsa05222 | Small cell lung cancer | 4 | 0.017791047 | MAX, RXRA, ITGA2B, PIK3R2 |
| hsa04915 | Estrogen signaling pathway | 4 | 0.026525517 | GNAO1, SP1, ESR1, PIK3R2 |
| hsa04919 | Thyroid hormone signaling pathway | 4 | 0.038861334 | NCOA3, RXRA, ESR1, PIK3R2 |
| hsa04150 | mTOR signaling pathway | 3 | 0.054897616* | EIF4B, RPS6KB1, PIK3R2 |
| hsa03013 | RNA transport | 6 | 0.005016166 | EIF3C, EIF4B, EIF3E, PABPC3, PABPC1, NUP210L |
*, not significant