Table 1.
Association between the Telomere-Related Polymorphisms and IPF Risk
| Polymorphism | No. of cases/ controls |
Adjusted OR a (95% CI) |
|||
|---|---|---|---|---|---|
| Codominant model | Dominant model | Recessive model | |||
| TERT rs2736100 (T>G) | TT+TG vs. GG | TT vs. TG+GG | |||
| TT | 82 / 137 | 1.00 (Reference) | 2.88 (1.31–6.34) | 2.41 (1.14–5.09) | 1.76 (1.06–2.91) |
| TG | 57 / 171 | 0.68 (0.39–1.17) | 1.96 (0.88–4.37 | 1.00 (Reference) | |
| GG | 16 / 71 | 0.35 (0.15–0.76) | 1.00 (Reference) | 1.00 (Reference) | |
| Ptrend =0.008 | Ptrend =0.008 | ||||
| TERC rs1881984 (T>C) | TT+TC vs. CC | TT vs. TC+CC | |||
| TT | 79 / 160 | 1.00 (Reference) | 1.36 (0.62–2.98) | 1.29 (0.61–2.69) | 1.18 (0.71–1.96) |
| TC | 60 / 165 | 0.89 (0.52–1.53) | 1.21 (0.55–2.67) | 1.00 (Reference) | |
| CC | 16 / 54 | 0.73 (0.34–1.61) | 1.00 (Reference) | 1.00 (Reference) | |
| Ptrend =0.435 | Ptrend =0.435 | ||||
| OBFC1 rs11191865 (G>A) | GG+AG vs. AA | GG vs. AG+AA | |||
| GG | 84 / 173 | 1.00 (Reference) | 1.90 (0.83–4.37) | 1.57 (0.71–3.49) | 1.60 (0.97–2.65) |
| AG | 56 / 160 | 0.66 (0.38–1.13) | 1.25 (0.53–2.92) | 1.00 (Reference) | |
| AA | 15 / 46 | 0.53 (0.23–1.21) | 1.00 (Reference) | 1.00 (Reference) | |
| Ptrend =0.063 | Ptrend =0.063 | ||||
95% CI, 95% confidence interval; OR, odds ratio; a, Adjusted for age, sex and smoking status.