Table 2.
Association between the Telomere-Related Polymorphisms and COPD Risk
| Polymorphism | No. of cases/ controls | Adjusted OR a (95% CI) |
|||
|---|---|---|---|---|---|
| Codominant model | Dominant model | Recessive model | |||
| TERT rs2736100 (T>G) | TT+TG vs. GG | TT vs. TG+GG | |||
| TT | 154 / 137 | 1.00 (Reference) | 1.88 (0.97–3.64) | 1.99 (1.09–3.66) | 1.08 (0.68–1.72) |
| TG | 204 / 171 | 1.12 (0.67–1.83) | 2.09 (1.10–4.01) | 1.00 (Reference) | |
| GG | 59 / 71 | 0.53 (0.27–1.03) | 1.00 (Reference) | 1.00 (Reference) | |
| Ptrend =0.162 | Ptrend =0.162 | ||||
| TERC rs1881984 (T>C) | TT+TC vs. CC | TT vs. TC+CC | |||
| TT | 188 / 160 | 1.00 (Reference) | 1.88 (0.90–3.93) | 1.93 (0.96–3.88) | 1.09 (0.69–1.72) |
| TC | 190 / 165 | 1.06 (0.65–1.71) | 1.99 (0.95–4.16) | 1.00 (Reference) | |
| CC | 39 / 54 | 0.53 (0.25–1.11) | 1.00 (Reference) | 1.00 (Reference) | |
| Ptrend =0.244 | Ptrend =0.244 | ||||
| OBFC1 rs11191865 (G>A) | GG+AG vs. AA | GG vs. AG+AA | |||
| GG | 170 / 173 | 1.00 (Reference) | 1.09 (0.55–2.17) | 1.15 (0.60–2.17) | 0.95 (0.60–1.49) |
| AG | 189 / 160 | 1.10 (0.68–1.78) | 1.20 (0.61–2.38) | 1.00 (Reference) | |
| AA | 58 / 46 | 0.92 (0.46–1.82) | 1.00 (Reference) | 1.00 (Reference) | |
| Ptrend =0.958 | Ptrend =0.958 | ||||
95% CI, 95% confidence interval; OR, odds ratio; a, Adjusted for age, sex and smoking status.