Table 3.
Association between the Combination of Telomere–Related Genetic Polymorphisms and the Risk of IPF
| Presence of "at-risk" genotype |
Cases/controls | Adjusted OR a (95% CI) | P-value | Adjusted OR a (95% CI) | P-value | ||
|---|---|---|---|---|---|---|---|
|
TERC
|
OBFC1
|
TERT
|
|||||
| rs1881984 | rs11191865 | rs2736100 | |||||
| 0 | 0 | 0 | 13/73 | 1.00 (Reference) | 1.00 (Reference) | ||
| 1 | 0 | 0 | 17/56 | 1.22 (0.43–3.44) | 0.713 | 1.78 (0.77–4.08) | |
| 0 | 1 | 0 | 23/69 | 1.81 (0.69–4.70) | 0.224 | 0.176 | |
| 0 | 0 | 1 | 20/43 | 2.42 (0.89–6.55) | 0.083 | ||
| 1 | 1 | 0 | 20/44 | 3.06 (1.02–9.17) | 0.046 | 2.84 (1.20–6.73) | |
| 1 | 0 | 1 | 21/34 | 2.31 (0.82–6.47) | 0.111 | 0.018 | |
| 0 | 1 | 1 | 20/34 | 3.32 (1.12–9.82) | 0.03 | ||
| 1 | 1 | 1 | 21/26 | 3.50 (1.16–10.62) | 0.027 | 3.51 (1.16–10.59) | 0.026 |
| Ptrend = 0.003 | |||||||
95% CI, 95% confidence interval; OR, odds ratio; Based on recessive model; a, Adjusted for age, sex and smoking status.