Table 2.

Baseline Details and Post-treatment Endpoints Compared between the Metformin and the Placebo Groups

Variables	MFM group		Placebo group		p-value	p-interaction
	(n = 25)		(n = 24)
Pre-treatment Ki-67 (%), mean (SD)	52.8 (17.2)		51.8 (15.8)		0.874
Post-treatment Ki-67 (%), mean (SD)	29.6 (15.8)		46.2 (21.3)		0.003
Ki-67 index Difference (%), mean (SD)	-23.2 (19.1)		-5.6 (16.8)		0.001	0.001*
Ki-67 index different proportion#	-39.1 (42.1)		-3.3 (45.3)		0.006
Histology grade difference, n (%)					0.525
Same grade	17 (68.0)		19 (79.2)
Decrease grade	5 (20.0)		2 (8.3)
Increase grade	3 (12.0)		3 (12.5)

Abbreviations, SD, standard deviation; * p-value interaction of intervention and time from repeated-measure ANOVA analysis; # Difference proportion, [Pre-treatment Ki-67 – Post-treatment Ki-67] / Pre-treatment Ki-67