Table 4.

Ability of mirabegron and isoprenaline to increase cAMP levels in brown, brite, and white adipocytes

Mouse strain	Adipocyte	Ligand	Maximal effect a	pEC50	n
FVB/N	Brown	Isoprenaline	0.40 ± 0.02	7.93 ± 0.17	5
		Mirabegron	0.45 ± 0.02	7.76 ± 0.17	5
	White	Isoprenaline	0.19 ± 0.03	6.96 ± 0.57	5
		Mirabegron	NA	NA	5
	Brite	Isoprenaline	0.37 ± 0.02	7.26 ± 0.19	5
		Mirabegron	0.33 ± 0.03	6.42 ± 0.26	5
β3‐adrenoceptor knockout	Brown	Isoprenaline	0.48 ± 0.03	7.98 ± 0.26	7
		Mirabegron	0.17 ± 0.01	5.27 ± 0.51	7
	White	Isoprenaline	0.15 ± 0.02	7.34 ± 0.75	6
		Mirabegron	0.11 ± 0.02	7.37 ± 1.00	6
	Brite	Isoprenaline	0.17 ± 0.01	7.72 ± 0.29	6
		Mirabegron	NA	NA	6

NA, no response.

^aExpressed in pmol/well.