TABLE 1.

Strategies for Optimizing the Treatment of OvCa

Strategy	Example
Targeting morphomolecular OvCa type	Different agents used to target HGSOC (chemotherapy, PARP inhibitors) vs LGSOC (MEK inhibitors, aromatase inhibitors)
New clinical trial designs	Umbrella studies
New agents	Examples of DNA damage and repair inhibitors: prexasertib, adavosertib, and ATRi
Novel combinations of agents that target the tumor microenvironment in addition to the tumor	Addition of antiangiogenic agents (bevacizumab, cediranib) chemotherapy or targeted agent and immune-therapy combinations
Improved therapeutic delivery	Antibody-directed conjugates Targeted radiotherapy

Abbreviations: ATRi, ATR inhibitor; HGSOC, high-grade serous ovarian cancer; LGSOC, low-grade serous ovarian cancer; OvCa, ovarian cancer.