Comparison 4. Dual versus one antiplatelet agent for preventing early recurrence after ischaemic stroke or transient ischaemic attack.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
4.1 Myocardial infarction	3	11411	Risk Ratio (M‐H, Fixed, 95% CI)	1.38 [0.63, 2.99]
4.1.1 Aspirin + dipyridamole vs clopidogrel	1	1360	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.14, 7.25]
4.1.2 Aspirin + clopidogrel vs aspirin	2	10051	Risk Ratio (M‐H, Fixed, 95% CI)	1.45 [0.62, 3.39]
4.2 Stroke, myocardial infarction, or vascular death	7	12932	Risk Ratio (M‐H, Fixed, 95% CI)	0.72 [0.64, 0.82]
4.2.1 Aspirin + dipyridamole vs aspirin	2	638	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.42, 1.07]
4.2.2 Aspirin + dipyridamole vs clopidogrel	1	1360	Risk Ratio (M‐H, Fixed, 95% CI)	0.71 [0.38, 1.34]
4.2.3 Aspirin + clopidogrel vs aspirin	3	10443	Risk Ratio (M‐H, Fixed, 95% CI)	0.72 [0.64, 0.82]
4.2.4 Aspirin + clopidogrel vs clopidogrel	1	491	Risk Ratio (M‐H, Fixed, 95% CI)	0.81 [0.41, 1.59]
4.3 Intracranial haemorrhage	5	11217	Risk Ratio (M‐H, Fixed, 95% CI)	1.53 [0.76, 3.06]
4.3.1 Aspirin + dipyridamole vs aspirin	1	38	Risk Ratio (M‐H, Fixed, 95% CI)	2.71 [0.12, 62.70]
4.3.2 Aspirin + dipyridamole vs clopidogrel	1	1360	Risk Ratio (M‐H, Fixed, 95% CI)	Not estimable
4.3.3 Aspirin + clopidogrel vs aspirin	3	9819	Risk Ratio (M‐H, Fixed, 95% CI)	1.48 [0.72, 3.02]
4.4 Extracranial haemorrhage	6	7586	Risk Ratio (M‐H, Fixed, 95% CI)	3.08 [1.74, 5.46]
4.4.1 Aspirin + dipyridamole vs aspirin	2	638	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.06, 14.61]
4.4.2 Aspirin + dipyridamole vs clopidogrel	1	1360	Risk Ratio (M‐H, Fixed, 95% CI)	1.19 [0.40, 3.54]
4.4.3 Aspirin + clopidogrel vs aspirin	2	5097	Risk Ratio (M‐H, Fixed, 95% CI)	4.81 [2.19, 10.57]
4.4.4 Aspirin + clopidogrel vs clopidogrel	1	491	Risk Ratio (M‐H, Fixed, 95% CI)	3.67 [0.41, 32.62]
4.5 Ischaemic stroke	2	10051	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.61, 0.81]
4.5.1 Aspirin + clopidogrel vs aspirin	2	10051	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.61, 0.81]
4.6 Haemorrhagic stroke	2	10051	Risk Ratio (M‐H, Fixed, 95% CI)	1.19 [0.53, 2.64]
4.6.1 Aspirin + dipyridamole vs aspirin	2	10051	Risk Ratio (M‐H, Fixed, 95% CI)	1.19 [0.53, 2.64]
4.7 Death from any cause	3	11411	Risk Ratio (M‐H, Fixed, 95% CI)	1.19 [0.72, 1.96]
4.7.1 Aspirin + clopidogrel vs aspirin	2	10051	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.73, 2.23]
4.7.2 Aspirin + dipyridamole vs clopidogrel	1	1360	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.26, 2.78]