POINT.

Study characteristics
Methods	RCT
Participants	Individuals with high‐risk TIA (defined as an ABCD2 score > 4) or minor ischaemic stroke (with NIHSS < 3) and study drug administered within 12 hours of time last known free of new ischaemic symptoms
Interventions	Clopidogrel plus aspirin versus aspirin alone
Outcomes	Primary outcome: new ischaemic vascular events (ischaemic stroke, MI, and ischaemic vascular death) Secondary outcomes: risk of ischaemic stroke, intracranial haemorrhage, and major haemorrhage, and composite of the primary outcome and major haemorrhage
Notes	Subgroup analysis at 30 days
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random selection by computer software
Allocation concealment (selection bias)	Low risk	Allocation concealed.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blinding
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Blinded outcome assessment by independent study group
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants accounted for as lost to follow‐up or ceased treatment
Selective reporting (reporting bias)	Low risk	All pre‐specified outcomes reported