THALES 2018.

Study name	THALES
Methods	RCT
Participants	Participants are ≥ 40 years of age with non‐cardioembolic ischaemic stroke of NIHSS of ≤ 5 or high‐risk TIA (defined as ABCD2 score of ≥ 6 or with ipsilateral large vessel stenosis of ≥ 50%). Participants are randomised within 24 hours of the time last known free of new ischaemic symptoms, and study drug is administered immediately afterwards.
Interventions	Ticagrelor and aspirin compared with aspirin
Outcomes	The primary efficacy outcome is time from randomisation to first subsequent stroke or death through 30 days of treatment. The primary safety outcome is time to first severe bleeding event based on the GUSTO definition.
Starting date	22 January 2018
Contact information
Notes	Met primary endpoint as presented at International Stroke Conference, final results pending.

GUSTO: Global Use of Strategies To Open up coronary arteries
NIHSS: National Institutes of Health Stroke Scale
RCT: randomised controlled trial
TIA: transient ischaemic attack