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. Author manuscript; available in PMC: 2020 Aug 19.
Published in final edited form as: Biochem J. 2020 Mar 13;477(5):1021–1031. doi: 10.1042/BCJ20190570

Figure 2. AKT2 loss suppresses glucose excursion induced by pyruvate in the absence of insulin/nutrient signal.

Figure 2.

(A) Fasting plasma glucose levels determined in Akt2+/+ (A+/+) and Akt2−/− (A−/−) mice fasted for 16 h. (B) Random fed plasma glucose levels. (C) Insulin tolerance test (ITT) performed in Akt2+/+ (A+/+) and Akt2−/− (A−/−) mice fasted for 6 h. (D) Expression of PEPCK and G6Pase in Akt2+/+ and Akt2−/− mice fasted for 16 h. n = 3. (E) Pyruvate tolerant test (PTT) in Akt2+/+ (A+/+) and Akt2−/− (A−/−) mice fasted for 16 h. Data presented as mean ± SEM. * P ≤ 0.05.